Five-year OS data from KEYNOTE-024, which evaluated KEYTRUDA monotherapy versus chemotherapy for the first-line treatment of patients with metastatic NSCLC whose tumors expressed PD-L1 (tumor proportion score ≥50%), were presented at ESMO 2020. Results from KEYNOTE-189 (abstract #973MO) and KEYNOTE-407 (abstract #974MO) are being presented during a mini oral session at the European Society for Medical Oncology (ESMO) Congress 2022. “These results show meaningful improvements in five-year survival for patients receiving KEYTRUDA plus chemotherapy and reinforce the important role of these KEYTRUDA-based regimens as standards of care for metastatic non-small cell lung cancer.” Garassino, professor of medicine, University of Chicago, Hematology/Oncology, and principal investigator for KEYNOTE-189. “Prior to these landmark studies, lung cancer had a 10% five-year survival rate, one of the lowest of any cancer,” said Dr. In fact, in both studies, of the approximately 55 patients who completed two years of treatment, about 70% were alive at five years.” “Now, with more than five years of follow-up, these studies continue to show impressive survival outcomes and durable responses for patients receiving KEYTRUDA in combination with chemotherapy. Eliav Barr, senior vice president, head of global clinical development and chief medical officer, Merck Research Laboratories. “The overall survival findings from KEYNOTE-189 and KEYNOTE-407 changed the way patients with metastatic non-small cell lung cancer were treated and established KEYTRUDA plus chemotherapy as a foundational first-line treatment for this devastating disease,” said Dr. In addition to NSCLC, five-year survival data for KEYTRUDA have been presented in three other types of cancer, including bladder cancer (KEYNOTE-045), head and neck cancer (KEYNOTE-048) and melanoma (KEYNOTE-054). KEYTRUDA is the first immunotherapy to demonstrate a sustained five-year survival benefit both in combination with chemotherapy and as monotherapy for the first-line treatment of NSCLC. The median OS was 17.2 months for the KEYTRUDA plus chemotherapy group versus 11.6 months for the chemotherapy group. KEYTRUDA plus carboplatin-paclitaxel or nab-paclitaxel reduced the risk of death by 29% (HR=0.71 ) versus chemotherapy alone. At five years, KEYTRUDA plus pemetrexed and cisplatin or carboplatin more than doubled the median OS compared to chemotherapy alone (22.0 months versus 10.6 months) įor patients with metastatic squamous NSCLC, results from KEYNOTE-407 showed the five-year OS rate for KEYTRUDA plus carboplatin-paclitaxel or nab-paclitaxel was 18.4% versus 9.7% for chemotherapy alone. The KEYTRUDA-pemetrexed-platinum chemotherapy combination reduced the risk of death by 40% (HR=0.60 ). RAHWAY, N.J.-( BUSINESS WIRE)-Merck (NYSE: MRK), known as MSD outside of the United States and Canada, today announced KEYTRUDA, Merck’s anti-PD-1 therapy, plus chemotherapy continued to demonstrate a survival benefit and durable responses in two five-year exploratory analyses of pivotal Phase 3 studies as first-line treatment for metastatic non-small cell lung cancer (NSCLC):įor patients with metastatic nonsquamous NSCLC, data from KEYNOTE-189 demonstrated KEYTRUDA plus pemetrexed (ALIMTA ®) and platinum chemotherapy (cisplatin or carboplatin) had a five-year overall survival (OS) rate of 19.4% versus 11.3% for chemotherapy alone.
0 Comments
Evaluate multi-unit and commercial properties.Print the performance projection to an AirPrint-compatible printer.Email the performance projection to your clients, lenders, or investment partners as a PDF file.Save multiple properties or what-if scenarios. YOU CAN UPGRADE TO THE PREMIUM OR PRO VERSIONS WITHIN THE APP TO ACCESS THE ADDITIONAL FEATURES LISTED BELOW.ĪDDITIONAL FEATURES IN THE PREMIUM VERSION:
Heedless of the blood dripping from the gash on her forehead, she yells for Do-hyun to stop being scared and come out. Shaking off the pain, Ri-jin climbs up next to him and throws him to the lower level of the roof.Īs Yo-sub struggles, Ri-jin grabs him by the collar and starts to call Do-hyun by name. Yo-sub looks dismayed to see her hurt, but he turns to the ledge nevertheless. She crashes into bundles of poles, which land on her head and inflict a nasty gash. Ri-jin grabs at Yo-sub’s leg, but he shakes her off. “If you wanted to save us,” he tells her, “you shouldn’t have been late.” But Yo-sub holds up two fingers, since she was two minutes late in finding him. “Come down,” Ri-jin says, holding out her hand. You don’t even have the courage to fight!” I live every day fighting against the me who just wants to give up. There’s the me who wants to live, and the me who wants to die. Ri-jin” “Everyone has several people living inside of them. He’s tired of living this way, as a mutant, never knowing which personality will control the body next. Yo-sub believes he’s only doing what the others don’t have the courage to do. Ri-jin confronts Yo-sub, telling him he doesn’t have the right to die when he pleases, since he shares the body. “NO!” Ri-jin’s shout makes him freeze, and Yo-sub turns away from the ledge. He leans forward, arms spread to the sky. Rising to his feet, he advances to the edge and balances on one foot. He checks his watch and sees that the hour is up. She recreates the scene in her mind, watching Yo-sub purchase art supplies and then head across the street to a building that is conveniently closed for remodeling.Īfter painting all seven personalities as his dying message, Yo-sub waits on the rooftop of the building. Ri-jin sees a craft store, which triggers her memory of the sound of Yo-sub’s spray bottle over the phone. “Until my son comes back,” she says, “that child must be protected.” And what happens after that, I wonder? She only wants Chief Ahn to make sure Ki-joon’s father doesn’t figure out the secret and use it to gain power. “I don’t care what he’s hiding, or what secrets he has,” she declares. I have to at least try.”Ĭhief Ahn prepares to tell Grandma Seo the answers to her questions, but it turns out that she’s not interested. “I’m taking chances-I’m either right or wrong. Ri-jin sees a skyscraper in the distance that gives her an idea, and she ends her call with Dr. They know he won’t be at the company, because there are too many people and CCTVs for him to be able to wait for an hour without anyone noticing. Seok realizes that he must be on a rooftop somewhere. When Ri-jin relays Yo-sub’s words about the sky becoming his grave, Dr. She learns that aside from having suicidal tendencies, Yo-sub is seventeen, a painter who hates anything ugly, and has a near genius-level intellect. When Chief Ahn doesn’t pick up the phone, Ri-jin calls Dr. “What secret is he hiding from me?” demands Grandma Seo. There must be a reason he never came back, not even when his mother called him, and that reason is probably connected with why he is determined to return to America in three months. She knows Do-hyun’s problem can’t be anything as simple as a hidden woman somewhere, because he practically exiled himself to America when he was only fifteen. Step by step, Grandma Seo lays out the things that made her suspicious. Ri-jin tries to call Chief Ahn, but he cannot answer as he is still being interrogated by Grandma Seo. This brings us to Yo-sub arriving at the rooftop, and the challenge to find him in one hour that ended last week’s episode. Chief Ahn sees Do-hyun walking away from the company, and although it seems strange he can’t get out of the car without rousing Grandma Seo’s suspicions. She has noticed that something is off about Do-hyun, and is searching for answers. While heading back to the company Chief Ahn runs into Grandma Seo, who tells him to get into her car. Chief Ahn didn’t think anyone had ever seen the author’s face, but Ri-on replies that he’s only repeating the rumors. He greets Chief Ahn and observes impishly that the author of Omega-3 is supposed to be very handsome, I mean really handsome, like Won Bin level. Who else should sidle up next to him but Ri-on, the Omega writer himself. Chief Ahn looks through a display case of Omega-3 murder mysteries at a bookstore, as part of his search for the elusive author. We back up a little to fill in some of the gaps before last week’s cliffhanger (so to speak). Do-hyun’s enemies are all around, even inside his mind-what difference can a lone psychologist-in-training really make? That question haunts Ri-jin as she comes to face her most difficult decision yet. With Do-hyun in more danger than ever, Ri-jin has to figure out what lengths she’s willing to go to protect him. 227 FebruJanuKill Me, Heal Me: Episode 7 by purplecow Get translate your documents from / to Polish language including Nikah Nama, Birth Certificate, Educational Degrees, Medical Certificate, Police Verification Certificate, Polish CV / Resume services, Polish Visa form filling, Polish Application form, Polish thesis services, brochures and all other documents. Polish interpreters / translators can be arranged for your next project anywhere in Pakistan at best prices by Translation.pk at your convenience. * Note: Pricing depends on language, number of words, complexity and legalityįor professional & reliable translation services from Polish to any other language including Arabic, Balochi, Check Republic, Chinese, Dutch, English, French, German, Greek, Hindi, Italian, Japanese, Korean, Latin, Pashto, Polish, Portuguese, Punjabi, Russian, Sindhi, Spanish, Urdu or any other language and vice versa, you can contact us for cheap Polish Translation Quote. Here are Translation.pk Polish translation rates:Īrabic, Balochi, Check Republic, Chinese, Dutch, English, French, German, Greek, Hindi, Italian, Japanese, Korean, Latin, Pashto, Polish, Portuguese, Punjabi, Russian, Sindhi, Spanish, Urdu and many other languages Our polish translators are qualified and expert in their work.Īlthough Translation.pk translation rates are very cheap but we provide most reliable, trustworthy and best polish translation. Translation.pk translation services are very reliable. We have expert polish translators, polish interpreters from all languages including Arabic, Balochi, Check Republic, Chinese, Dutch, English, French, German, Greek, Hindi, Italian, Japanese, Korean, Latin, Pashto, Polish, Portuguese, Punjabi, Russian, Sindhi, Spanish etc. We do polish translate all kind of letters and documents in almost all languages. Translation.pk is specialist in providing certified professional polish translation services in all major cities of Pakistan including Karachi, Lahore, Islamabad, Rawalpindi, Faisalabad, Peshawer, Quetta, Sialkot, Gujrat, Multan, Hyderabad, Bahawalpur and all other cities. Southern Kresy dialect sub dialects are Lwów dialect. Northern Kresy dialect is also very important dialect of Polish, its sub groups are Bialystok dialect, Wilno dialect, and Suwalki dialect. Then Lesser Polish dialect its sub groups are Lowicz dialect, Sieradz-Leczyca dialect, Holy Cross Mountains dialects, Grebów dialect, Orawa dialect, Spisz dialect, and Podhale dialect. Then Mazovian dialect its sub dialects are Podlasie-Suwalki dialect, Warmia dialect, Kurpie dialect, Masurian dialect, Malbork-Lubawa dialect and Ostróda dialect. Polish has different dialects like Greater Polish dialect it has also sub dialects like Krajna dialect, Tuchola dialect, Kociewie dialect, Chelmno-Dobrzyn dialect, Cuyavian dialect and Chojno dialect. It has almost 40 million speakers all over the world. It is usually spoken in Poland, Belarus, Argentina, France, Ukraine, Lithuania, Israel, Latvia, Vietnam, UK, USA, Russia, Brazil, Canada, Australia, Romania, Ireland, Czech Republic and Germany. It is 3rd mostly spoken Slavic language after Ukrainian and Russian. Polish is an official language of Poland. Salt Lake City International Airport Distance from Property: 6.3 Miles. 625 South 300 West, Salt Lake City, Utah, USA, 84101. Check current conditions in Salt Lake City, UT with radar, hourly, and more. The Best Salt Lake City RestaurantsHourly weather forecast in Salt Lake City, UT. Wander out of the lobby and the area is awash with shops and dining options. Close to Temple Square and Salt Palace Convention Center, this well-appointed hotel boasts fabulous views, while the on-site restaurant, Salt Stone, is a cut above most hotel eateries. S.Salt Lake City, UT 84101 Email agent Brokered by Equity Real Estate - Advantage Contingent $570,000 2 bed 2 bath 1,120 sqft 3,485 sqft lot 226 W Montrose Ave, Salt Lake City, UT 84101 Email.75 South West Temple, Salt Lake City, UT 84101. 55 North 400 West, Salt Lake City, Utah, United States, 84101 +1 8 714 Reviews. Salt Lake City, UT 84101 Driving Directions Connect with Us General Info: 385 - 468 - 1010 ArtTix Phone: 801 - 355 - ARTS (2787) Event Booking: 385 - 468 - 1030 …Hyatt Place Salt Lake City/Downtown/The Gateway. Couples in particular like the location – they rated it 9.2 for a …50 W 200 S. Mostly sunny.This is our guests' favorite part of Salt Lake City, according to independent reviews. PSČ 84101 – Vyhľadávanie PSČ miest a obcí na Slovensku, zoznam PSČ Slovensko, jednoduché vyhľadávanie PSČ, praktické zobrazenie PSČ na mape.TOMORROW’S WEATHER FORECAST. Salt Lake City, South Salt Lake, and North Salt Lake are nearby cities. Downtown and Central City are nearby neighborhoods. This building is located in Salt Lake City in Salt Lake County zip code 84101. Phone Number: +1 800-595 …PSČ 84101 – Vyhľadávanie PSČ miest a obcí na Slovensku, zoznam PSČ Slovensko, jednoduché vyhľadávanie PSČ, praktické zobrazenie PSČ na mape.Chateau Foret Condominiums. Salt Lake City, UT Weather Forecast | AccuWeather Hourly Daily Radar MinuteCast Monthly Health & Activities Current Weather 2:17 AM 59° F RealFeel® 54° Air Quality Fair Wind NW 12 mph Wind Gusts.625 South 300 West, Salt Lake City, Utah, USA, 84101. Enjoy a modern …Salt Lake City, UT 84101 Email agent Brokered by Equity Real Estate - Advantage Contingent $570,000 2 bed 2 bath 1,120 sqft 3,485 sqft lot 226 W Montrose Ave, Salt Lake City, UT 84101 Email. 84101 Take in natural sunlight or evening downtown Salt Lake City lights through floor-to-ceiling windows from the 6th-floor location, adjacent to the pool. If you were a party and didn’t like the circuit court’s decision, you have a right to appeal. Only a party in the circuit court case can appeal a decision. A chance to present new evidence or witnesses. A chance to present your case in front of a different judge, or.Situations where the evidence did not support the outcome reached by the circuit court or jury.Legal or factual errors by the circuit court or jury,.You must make appeals on valid grounds, such as: Report of proceedings or transcripts of court hearings,.The common law record which includes all the documents filed in your case, every judgment entered, and any document exhibits,.The only information the appellate court will review is: The person making the appeal is called the “appellant.” The person responding to the appeal is called the “appellee.”Īn appeal is not a new trial. If the higher court disagrees, it can change the lower court’s decision. What is an appeal?Īn appeal is a review by a higher court of a lower court's decision. You can search for a lawyer to represent you at Illinois Lawyer Finder or talk to a lawyer at Get Legal Help. Write briefs in order to convince the appellate court that your position is correct.If you appeal your case without a lawyer, you will need to: You must follow the Illinois Supreme Court Rules. This is called a “civil appeal” because it is different from criminal appeals. If we want to make it clear what partial ordering the lattice is based on, we say it is a lattice under. Since a lattice L is an algebraic system with binary operations and, it is denoted by L. Variants on compound cubic lattices are obtained by scaling one of the parent elementary sub-lattices by an integer value of ≥2. A lattice is a poset (L, ) for which every pair of elements has a greatest lower bound and least upper bound. Examples of low-order lattice topologies include (e) elementary cubic, (f) compound cubic, (g) super compound cubic, (h) the Kagome lattice, and (i) the diamond lattice. (e–o) Lattice structures and lattice defects are distinctly different from those in traditional materials science. (a–d) Pertinent length scales in traditional materials science are well established: grains are typically 10–100 µm in size, precipitates 10–100 nm, dislocation spacings 10–100 nm, and solute atoms and vacancies at the sub-nm level. Although these characteristics are relevant to the constituent materials from which lattices are made, descriptions of the lattice structure itself require other concepts.Ĭontrasting elements of structure and defects in traditional materials science and in lattice materials science. : a lattice or work made of lattices Example Sentences the intricate latticework of the fence Recent Examples on the Web Behind latticework beneath the deck of his large house on a dead end street, archaeologists working for police in March 2021 found a soil disturbance about the size of a casket and the presence of human blood, prosecutors said. Some of the important structural characteristics-including crystalline grains, grain and interphase boundaries, dislocations, precipitates, solute atoms, and vacancies-are depicted schematically in Figs. Here, structure encompasses the organization of atoms or molecules relative to one another, often in the form of crystals boundaries between domains of differing orientation and,or composition and defects that disrupt periodic arrangements at length scales ranging from the atomic to the macroscopic. The field of materials science as an academic discipline is founded principally on relationships between processing, structure, and properties (Fig. In establishing relationships between macroscopic properties and lattice structure, questions arise about the nature of structure of lattice materials and how characteristics of structure can be integrated into the materials science paradigm. Lattice materials comprising periodic arrays of interconnected struts have emerged as a new class of engineering materials with potential for use in an incredibly diverse range of applications, including structural biomedical implants, aerospace and naval structures, force protection systems, thermal management, actuation, high-performance running shoes, and photonic and phononic crystals, They can be designed to exhibit unusual properties, including negative thermal expansion, negative Poisson’s ratio, fluid-like elasticity (with an extraordinarily high ratio of bulk to shear moduli), unusually high damping capacity, and negative mass density, When the arrays are large, with individual unit cells being small relative to macroscopic length scales of interest, lattices can be treated effectively as other engineering materials in the sense that their properties can be couched in terms of their volume-averaged response to external stimuli. His mother came to visit him there, and wept over the dismal turn his young life had already taken. When he was 17-years-old, he was arrested on a concealed-weapons charge and landed in the Wayne County Jail. He quickly accumulated a juvenile criminal record for breaking and entering, purse-snatching, and shoplifting. “I fell victim to the peer pressures that went along with the environment, ” Mathis recalled in the Detroit News.Īt the age of 15, Mathis became involved with an infamous Detroit gang, the Erroll Flynns. He attended three different high schools before dropping out in the tenth grade. From an early age, Mathis had a problem with discipline, and was even expelled from elementary school. Alice Mathis raised her sons there as a single mother, and worked two jobs -the midnight shift in a hospital as a nurse ’s aide, and as a cleaning woman during the day -in order to make ends meet. The family lived in one of the first federal housing projects in the United States, Herman Gardens, which by the time of his adolescence had earned a reputation as a tough, dangerous environment. Mathis was born in 1960 in Detroit, one of four sons born to Alice Mathis. Now my inspirational justice might do the same thing for many more people in the living rooms of America. “I think I was able to influence 15 to 20 people a week -a handful of lives. “I had a commitment to changing lives, ” he told Detroit News television critic Tim Kiska about his time on the bench of Detroit ’s 36th District Court. Judge Mathis debuted in 1999 as one of several reality-based court television programs in syndication, and Mathis viewed the career move to television as part of a natural progression of his mission in life. He negotiated a film and book deal with the Warner Entertainment Group, which created the Judge Mathis show. Before he turned 40-years-old, Mathis ’s unusual life story had already attracted the attention of Hollywood producers. Mathis has always stressed that it was the wisdom and faith of a kind judge that helped change his life. But the no-nonsense jurist had already tasted a certain degree of celebrity in his hometown, Detroit, as a former gang member who went to law school and was eventually elected as a judge his life story became the basis for a local play. As one of the several real-life judges who have moved into televised studio courtrooms as hosts of reality-based dispute-resolution shows, Greg Mathis enjoys solid ratings for his hour-long Judge Mathis television show. He goes around the world preaching to people who are willing to listen about juice fasting and how it changed his sickly world. I mean is it really worth it? Do I make enough money and do I have the will power? Well Joe cross seems to think anyone and everyone can do it. To juice fast or not to juice fast is the question, well the question I ask myself watching this movie. This documentary is directed by Kurt Engefr who also directed a controversial film Fahrenheit 9/11 and the first Fat Sick and Nearly Dead. He takes us on his continuation of his journey of juice fasting. In short, not really enough here to warrant a straight-to-video release.įat Sick and Nearly Dead 2 starts off with its main actor Joe Cross, an Australian wellness guru. Kudos to Joe to tempering his message this time and pointing out that good health is actually a pretty simple affair. A couple of boring experts are also thrown in. Anyway, the actual documentary presents a combination of a sadder and lonelier Joe looking for juice in cities he can't remember landing in, some low budget animation and brief man-on-the-street interviews about people thinking about drinking juice. To give you the short version moving to Detroit was the least of Phil's bad decisions in the intervening years between documentaries. Unfortunately, they all want to ask about Phil, (who plays the John-the-Baptist role to Joe) and Joe is forced to say in one scene: "Everyone asks about Phil and, you know, this doesn't always work for everyone". And he now has a worldwide (including the one person in Africa whom we meet) network of juiceheads to back him up. However, he's still juicin' (although he admits 30% of his calories come from the "processed" category). Some years have gone by and things haven't gone that well for Joe who reveals there is another 20 pounds of him after break-ups both romantic and financial. In part one, Australian financier and juice-pusher Joe Cross documented himself dropping pounds and helping tubby truck driver Phil avoid an early coronary by encouraging people to consume only juiced vegetables. Technically speaking there's nothing too great about this picture but fans of the first will still want to check it out. The most interesting aspect comes from visiting with Phil, the truck driver from the first film who fell on hard times and ended up gaining most of his weight back. For the most part I thought this was an entertaining film and like the first it's mainly here to try and educate people as well as teach them that there is support out there if they're needing it. The film proves that most people can juice for a week but after that it becomes a lot harder as there are just so many foods out there and of course personal drama that might cause humans to seek food as relief. This documentary tries to help people for the long haul and not just for a quick, sixty-day period. Whereas the first film showed us how much weight could be lost due to juicing, this sequel pretty much tells us that it's impossible to juice every single day and stay 100% healthy the rest of our lives. FAT, SICK & NEARLY DEAD 2 isn't quite as good as the original film but I think it's a worthy follow-up. We learn that he went through some financial and relationship drama, which caused him to gain some of his weight back and this starts the new journey. Fat, Sick & Nearly Dead 2 (2014) ** 1/2 (out of 4) Sequel to the 2010 mega-hit has Joe Cross returning to educate people on what has happened since the previous film. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |